Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ant308 (TFA) | 99.6% | 3467.10 (free base) | 1 MG
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist that significantly enhances the activation and proliferation of T cells. It inhibits the migration and metastasis and induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling. This compound reduces the expression of MCAM and N-cadherin, making it suitable for studies on acute myeloid leukemia (AML) and uveal melanoma (UVM).
- Vasoactive intestinal polypeptide (VIP receptor) antagonist
- Enhances T cell activation and proliferation
- Inhibits migration and metastasis of melanoma cells
- Induces apoptosis in melanoma tumor cells
- Inhibits VIP-VPAC2 signaling
- Reduces MCAM and N-cadherin expression
- Useful for acute myeloid leukemia (AML) research
- Useful for uveal melanoma (UVM) research
Medchemexpress LLC Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 4X100G
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 4X100G
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 | 25 MG
Pep42 TFA is a cyclic peptide ligand of GPR78. It internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process. This product is for research use only.
- Cyclic peptide ligand of GPR78
- Internalizes selectively into highly metastatic human melanoma cells
- Receptor-mediated process
- Sequence: Cys-Thr-Val-Ala-Leu-Pro-Gly-Gly-Tyr-Val-Arg-Val-Cys (disulfide:Cys1-Cys13)
- Target: Others
- Pathway: Others
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
- Appearance: Solid
- Stable under recommended storage conditions
- Identified uses: Laboratory chemicals, manufacture of substances
Medchemexpress LLC Jbsnf-000028 TFA | C13H14F3N3O2 | 5 MG
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models and is used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT).
- Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells.
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity.
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 5 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
- Shipping: Room temperature in continental US
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light, under nitrogen)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light, under nitrogen)
- Solubility (H2O): 100 mg/mL (needs ultrasonic)
- Solubility (DMSO): ≥ 100 mg/mL
- Related classifications: Peptides, Peptide and derivatives, Peptides for drug delivery, Cell-penetrating peptides
- Disease areas: Infection, Anti-infection HIV
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC C-telopeptide TFA | 868.89 (free base) | 25 MG
C-telopeptide TFA is a cross-linked peptide of type I collagen. It is released during bone resorption and has been correlated with bone mineral density (BMD). This product is intended for research use only.
- Cross-linked peptide of type I collagen
- Released during bone resorption
- Correlated with bone mineral density (BMD)
- Sequence: Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
- Target: MMP
- Pathway: Metabolic Enzyme/Protease
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Siivfekl (Tfa) | 99.85% | 948.16 | 1 MG
SIIVFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It is designed to stimulate specific T cells in experimental settings to study the competitive interaction between T cells. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for the detection of CD8+ T cells.
- Variant of the major MHC class I-restricted epitope SIINFEKL
- Stimulates specific T cells for competitive interaction studies
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Suitable for detection of CD8+ T cells
- High purity of 99.85%
- Provided as a white to off-white solid
- Stable under recommended storage conditions
Medchemexpress LLC FStAx-35R TFA | 97.4% | 2885.36 (free base) | 1 MG
fStAx-35R TFA is a hydrocarbon-stapled peptide that inhibits the Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. It can be utilized in cancer research.
- Inhibits Wnt/β-catenin signaling pathway
- Disrupts β-catenin-TCF interaction
- Suitable for cancer research
Medchemexpress LLC Galantide (TFA) | 98.1% | 2313.55 | 500 UG
Galantide TFA is a synthetic peptide known to act as a galanin receptor antagonist. It is provided in a high purity powder form, suitable for various laboratory applications.
- High purity powder
- Acts as a galanin receptor antagonist
- Suitable for laboratory research
Medchemexpress LLC CREBtide TFA | 98.7% | 1716.99 (free acid) | 5 MG
CREBtide TFA is a synthetic 13 amino acid peptide, a CREB (cAMP response element binding protein)-like peptide. It functions as a substrate for both Protein Kinase A (PKA) and Protein Kinase C (PKC).
- Solid appearance
- White to off-white color
- Amino acid sequence: Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
- Reported as a PKA and PKC substrate
- Apparent Km of 3.9 μM for phosphorylation by cAK
- Apparent Km of 2.9 μM for phosphorylation by cGK